Different Correlations of Drug Susceptibilities to Colonial Morphology in <i>Mycobacterium avium</i> Complex Strains
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- TSUKAMURA Michio
- Department of Microbiology, Fujita Gakuen Health University Medical School
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- MIZUNO Shoji
- The National Chubu Hospital
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- MIYAMA Akio
- Department of Microbiology, Fujita Gakuen Health University Medical School
抄録
In Mycobacterium avium and Mycobacterium intracellulare complex strains isolated from patients who were not treated previously by any antituberculosis drugs or from fowls, the colonial morphology, smooth, domed, opaque (SmD) or smooth, flat, transparent (SmT) colonial forms, significantly correlated with susceptibilities to rifampicin, minocycline, streptomycin, kanamycin, enviomycin, ethambutol, and sulfadimethoxine, whereas it did not correlate with susceptibilities to isoniazid, cycloserine, and ethionamide. Strains with the SmT colonial morphology were more resistant to the former seven drugs than strains with the SmD colonial morphology. Since the susceptibilities to antituberculosis drugs with large molecules correlated with the colonial morphology, it has been suggested that a permeability barrier that allows passage of small molecules but prevents passage of large molecules exists in the strains with the SmT colonial morphology.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 33 (12), 1001-1011, 1989
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1572261552988805632
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- NII論文ID
- 130003483542
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles