Immunopathology of Chronic Progressive Hepatitis in Nude Mice Infected with Low-Virulent Mouse Hepatitis Virus

J-STAGE
  • MIDORO Katsuo
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
  • NAKANAGA Kazue
    Department of Animal Pathology, Institute of Medical Science, The University of Tokyo
  • KYUWA Shigeru
    Department of Animal Pathology, Institute of Medical Science, The University of Tokyo
  • FUJIWARA Kosaku
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo

Abstract

Progressive hepatitis in athymic nude (nu/nu) mice due to a low-virulent mouse hepatitis virus, MHV-2 cc, was examined for involvement of immunocytes and serum antibodies. At 3 to 6 weeks postinoculation (p.i.) a considerable number of Mac 1- and asialo GM1-positive cells were accumulated in the affected liver and spleen. There were also some Thy-1-positive cells. Later than 2 weeks p.i., serum IgG and IgM antibodies were detected in parallel with virus-neutralizing activity, while the IgG levels were lower than those of infected euthymic (nu/+) littermates. By transfer of the infected nu/nu mouse serum, the recipient euthymic mice acquired resistance to lethal challenge infection with a virulent virus, MHV-2.

Journal

Details 詳細情報について

Report a problem

Back to top