Changes in Interleukin 1 Levels in Human Amniotic Fluid with Gestational Ages and Delivery
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- TSUNODA Hajime
- Department of Obstetrics and Gynecology, Institute of Clinical Medicine
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- TAMATANI Takuya
- Department of Microbiology, Institute of Basic Medical Science, University of Tsukuba
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- OOMOTO Yasukazu
- Department of Immunology, Otsuka Pharmaceutical Co., Ltd.
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- HIRAI Yoshikatsu
- Department of Immunology, Otsuka Pharmaceutical Co., Ltd.
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- KASAHARA Tadashi
- Department of Medical Biology and Parasitology, Jichi Medical School
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- IWASAKI Hirokazu
- Department of Obstetrics and Gynecology, Institute of Clinical Medicine
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- ONOZAKI Kikuo
- Department of Microbiology, Institute of Basic Medical Science, University of Tsukuba
Abstract
In order to understand the role of interleukin 1 (IL-1) in pregnancy, the amount of IL-1 in normal human amniotic fluid (AF) from various gestational ages and delivery was measured using an ELISA. AF samples were divided into three groups of varying gestational ages. Group 1 of AF was collected by amniocentesis from gestational ages <24 weeks (n=13). Group 2 was collected transvaginally during delivery following labor ≥36 weeks (n=36). Group 3 was transabdominally collected from elective cesarean section without labor ≥36 weeks (n=8). IL-1α was present in AF of early gestational age, 19.2±21.7pg/ml, in group 1, and appeared to increase with gestational age, 63.4±50.1pg/ml, in group 3. In contrast, IL-1β was not detectable in either group 1 or 3. However, the concentration of IL-1 in group 2 was extremely high (IL-1α, 233.1±351.9pg/ml; IL-1β, 1, 093.5±1, 369.7pg/ml) compared to the other groups. Moreover, these concentrations tended to increase with the duration of labor. IL-1α and IL-1β concentrations in AF were intimately related. These findings suggest that IL-1 has some roles during pregnancy and especially during labor.
Journal
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- Japanese Journal of Microbiology
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Japanese Journal of Microbiology 34 (4), 377-385, 1990
Center For Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1570572703128409728
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- NII Article ID
- 130003483673
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- ISSN
- 03855600
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- Text Lang
- en
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- Data Source
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- CiNii Articles