Role of Type 1 and Type 3 Fimbriae on the Adherence and Pathogenesis of <i>Salmonella enteritidis</i> in Mice

• ASLANZADEH Jaber

  Department of Laboratory Medicine, University of Connecticut Health Center

• PAULISSEN Leo J.

  Department of Botany and Microbiology, University of Arkansas

抄録

Through hemagglutination tests two isogenic strains of Salmonella enteritidis were shown to possess type 1 fimbriae (strain V) and type 1 and type 3 fimbriae (strain A). The two strains bound to human buccal and mouse small intestine epithelial cells. Strain A attached to the epithelial cells more readily and in larger numbers in comparison to strain V. Adherence of both strains were sensitive to the presence of D-mannose and pretreatment of the epithelial cells with tannic acid did not promote D-mannose resistant type binding of strain A S. enteritidis to human buccal and mouse small intestine epithelial cells. Furthermore, results from LD₅₀ study indicated that, when the tests were carried out through oral inoculation of the mice the highly fimbriated stain A appeared to be more virulent. However, when the tests were carried out through intraperitoneal inoculation strain V was more virulent. These results indicate that adherence is a major contributing factor to the virulence of S. enteritidis and both type 1 and type 3 fimbriae contribute to this phenomenon.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 36 (4), 351-359, 1992

  Center For Academic Publications Japan

詳細情報

• CRID: 1571980078011065984
• NII論文ID: 130003483866
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00078621534?from=CiNii
• 本文言語コード: en
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