Augmentation of Host Resistance to <i>Candida albicans</i> Infection in Ascites Tumor-Bearing Mice

• OKAWA Yoshio

  Second Department of Hygienic Chemistry, Tohoku College of Pharmacy

• MURATA Yoshiko

  Second Department of Hygienic Chemistry, Tohoku College of Pharmacy

• KOBAYASHI Makiko

  Department of Microbiology, Tohoku College of Pharmacy

• SUZUKI Masuko

  Department of Microbiology, Tohoku College of Pharmacy

• SUZUKI Shigeo

  Second Department of Hygienic Chemistry, Tohoku College of Pharmacy

抄録

We found that the number of peripheral blood polymorphonuclear leukocytes (PMN) dramatically increased in both sarcoma 180 (S-180) and MM-46 mammary carcinoma (MM-46) ascites tumor-bearing mice, and mice required a remarkable resistance to Candida albicans infection via intravenous route. When the resistance was determined by number of cells of C. albicans in the kidney, a significant decrease in the number of fungal cells was observed in the kidneys of infected ascites tumor-bearing mice. An increase of active oxygen levels of PMN from ascites tumor-bearing mice was observed, suggesting that this factor is important in developing of resistance in ascites tumor-bearing mice. Additionally, a culture supernatant of tumor cells co-cultivated with bone-marrow cells in vitro increased the number of granulocytes and macrophages differentiated from the bone-marrow cells.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 36 (5), 517-521, 1992

  Center For Academic Publications Japan

詳細情報

• CRID: 1573105977917905536
• NII論文ID: 130003483883
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00078685420?from=CiNii
• 本文言語コード: en
• データソース種別:
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