Inflammatory and Phagocytic Response to Experimental <i>Campylobacter jejuni</i> Infection in Mice
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- Pancorbo Pedro L.
- Department of Microbiology, Faculty of Experimental Sciences, University of Jaen
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- Gallego Aurelia M.
- Service of Clinic Laboratory, Hospital "Ciudad de Jaén"
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- Pablo Manuel de
- Department of Microbiology, Faculty of Experimental Sciences, University of Jaen
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- Alvarez Carmen
- Department of Microbiology, Faculty of Experimental Sciences, University of Jaen
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- Ortega Elena
- Department of Microbiology, Faculty of Experimental Sciences, University of Jaen
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- Cienfuegos Gerardo Alvarez de
- Department of Microbiology, Faculty of Experimental Sciences, University of Jaen
抄録
After intraperitoneal inoculation with Campylobacter jejuni BALB/c, Swiss and DBA mice show a peritoneal inflammatory response of different intensity. Only BALB/c mice have a strong peritoneal response. Simultaneous intraperitoneal inoculation of C. jejuni plus FeCl3 increase both inflammatory response and phagocytic activity in Swiss mice, without production of diarrhea. Some thermostable compounds of C. jejuni have a very strong chemotactic activity against peritoneal cells of mice, whereas a diffusible, thermolabile and glutaraldehyde-resistant factor has an inhibitory effect over murine peritoneal cell phagocytosis. Bactericidal activity of peritoneal cells increased after in vitro re-challenge with C. jejuni. Bacteremia is present in all the mice strains tested, but the clearance is quick in DBA and slow in BALB/c and Swiss mice. These experiments confirm that in mice, peritoneal non-specific mechanisms of defense, such as macrophages, play an important role in order to control C. jejuni infection.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 38 (2), 89-95, 1994
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1572543027965598592
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- NII論文ID
- 130003484053
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles