Biological Activities of Lipopolysaccharide Isolated from <i>Vibrio cholerae</i> O139, a New Epidemic Strain for Recent Cholera in Indian Subcontinent

J-STAGE
  • Shimizu Tadayori
    Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka
  • Yanagihara Yasutake
    Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka
  • Isshiki Yasunori
    Department of Microbiology, School of Pharmaceutical Sciences, Josai University
  • Kawamata Yasuhisa
    Department of Microbiology, School of Pharmaceutical Sciences, Josai University
  • Kondo Seiichi
    Department of Microbiology, School of Pharmaceutical Sciences, Josai University
  • Hisatsune Kazuhito
    Department of Microbiology, School of Pharmaceutical Sciences, Josai University

Abstract

Biological activities of lipopolysaccharide (LPS) isolated from Vibrio cholerae O139, a new causative agent for recent cholera epidemic in Indian subcontinent, were investigated in comparison with those of LPS from O1 V. cholerae. V. cholerae O139 LPS exerted mitogenic activity, lethal toxicity and Shwartzman reaction to the same extent as those observed for O1 V. cholerae LPS, although these activities except for lethal toxicity were obviously lower than those of Salmonella typhimurium LT-2LPS used as a reference. It was, therefore, suggested that O139 LPS does not contribute to the high infective and pathogenic potentials of the V. cholerae O139 strain as in the case of O1 V. cholerae.

Journal

Details 詳細情報について

Report a problem

Back to top