A Unique Mutation of Glycoprotein Gene of the Attenuated RC-HL Strain of Rabies Virus, a Seed Virus Used for Production of Animal Vaccine in Japan

J-STAGE
  • Ito Hiroshi
    Department of Veterinary Public Health, Faculty of Agriculture, Gifu University
  • Minamoto Nobuyuki
    Department of Veterinary Public Health, Faculty of Agriculture, Gifu University
  • Watanabe Tomiyoshi
    Department of Veterinary Public Health, Faculty of Agriculture, Gifu University
  • Goto Hideo
    Department of Veterinary Public Health, Faculty of Agriculture, Gifu University
  • Rong Luo Ting
    Department of Veterinary Public Health, Faculty of Agriculture, Gifu University
  • Sugiyama Makoto
    Department of Veterinary Public Health, Faculty of Agriculture, Gifu University
  • Kinjo Toshio
    Department of Veterinary Public Health, Faculty of Agriculture, Gifu University
  • Mannen Kazuaki
    Animal Laboratory Center, Oita Medical University
  • Mifune Kumato
    Department of Microbiology, Oita Medical University
  • Konobe Takeo
    Kannonji Institute, The Research Foundation for Microbial Disease of Osaka University
  • Yoshida Iwao
    Kannonji Institute, The Research Foundation for Microbial Disease of Osaka University
  • Takamizawa Akihisa
    Kannonji Institute, The Research Foundation for Microbial Disease of Osaka University

抄録

Although the RC-HL strain of rabies virus is avirulent in adult mice, the amino acid at position 333 of its G protein is arginine, which is thought to be necessary for virulence in adult mice upon intracerebral inoculation of the virus. This result suggests that besides arginine at position 333, some other positions of G protein might also be involved in determining the virulence of rabies virus.

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