A Similar Expression Pattern of Adhesion Molecules between Intermediate TCR Cells in the Liver and Intraepithelial Lymphocytes in the Intestine
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- Ohtsuka Kazuo
- The Department of Immunology, Niigata University School of Medicine
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- Hasegawa Katsuhiko
- The Department of Immunology, Niigata University School of Medicine
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- Sato Kazunari
- The Department of Immunology, Niigata University School of Medicine
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- Arai Katsumitsu
- The Department of Immunology, Niigata University School of Medicine
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- Watanabe Hisami
- The Department of Immunology, Niigata University School of Medicine
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- Asakura Hitoshi
- The Third Department of Internal Medicine, Niigata University School of Medicine
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- Abo Toru
- The Department of Immunology, Niigata University School of Medicine
抄録
Two major populations of extrathymically differentiated T cells exist in the liver and intestine. Such T cells in the liver have TCR of intermediate intensity (i.e., intermediate TCR cells) and constitutively express IL-2 receptor β-chain (IL-2Rβ), whereas those in the intestine, especially intraepithelial lymphocytes, have TCR of bright intensity, consisting of a mixture of IL-2Rβ+ and IL-2Rβ-. All mature thymocytes and thymus-derived T cells seen in the peripheral immune organs are TCR-bright+IL-2Rβ- under resting conditions. When the expression pattern of adhesion molecules, including CD44, L-selectin, LFA-1 and ICAM-1, was compared among these T-cell populations, they displayed quite unique patterns of expression. All extrathymic T cells in the liver, intestine, and even other organs were CD44+L-selectin-LFA-I++ ICAM-1+, whereas thymocytes and thymus-derived T cells were CD44-L-selectin+LFA-1+ICAM-1-. This inverted expression of adhesion molecules between extrathymic T cells and thymus-derived T cells might be associated with their unique tissue-localization.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 38 (8), 677-683, 1994
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1572824502942341376
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- NII論文ID
- 130003484145
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles