Elevated Plasma Levels of P-Selectin (GMP-140/CD62P) in Patients with <i>Plasmodium falciparum</i> Malaria

J-STAGE
  • Facer Christine A.
    Malaria Laboratory, Department of Haematology, The London Hospital Medical College
  • Theodoridou Agapi
    Malaria Laboratory, Department of Haematology, The London Hospital Medical College

抄録

The plasma concentration of soluble P-selectin (GMP-140/CD62P/PADGEM), a selectin produced by activated platelets and endothelial cells, was quantitated in a group of adults and East African negro children presenting with either non-severe or severe (cerebral) malaria caused by Plasmodium falciparum. Sixty percent of adults with non-severe malaria had immunoreactive levels of P-selectin above 200ng/ml (the maximum recorded for any normal healthy adult in the assay) and 86% of all African children with malaria had concentrations above normal irrespective of their clinical categorization, and most exceeded the maximum limits of the assay (>640ng/ml). There was no correlation between P-selectin levels and parasitemia. These results raise the possibility that elevated soluble P-selectin in malaria may have an important beneficial anti-inflammatory function.

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