Heat Shock Proteins in the Human Periodontal Disease Process
-
- Ando Tomohiro
- Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical College
-
- Kato Tetsuo
- Department of Microbiology, Tokyo Dental College
-
- Ishihara Kazuyuki
- Department of Microbiology, Tokyo Dental College
-
- Ogiuchi Hideki
- Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical College
-
- Okuda Katsuji
- Department of Microbiology, Tokyo Dental College
Abstract
The production of HSP by periodontopathic Gram-negative bacteria was examined by SDS-PAGE, two dimensional gel electrophoresis, and Western blotting using monoclonal antibodies against HSPs. Strains of Actinobacillus actinomycetemcomitans, Eikenella corrodens, Fusobacterium nucleatum, Prevotella intermedia, Prevotella nigrescens, Prevotella melaninogenica, and Treponema socranskii species produced HSP which reacted with anti-Yersinia enterocolitica HSP 60 and/or mycobacterial 65-kDa HSP monoclonal antibodies. It was found that gingival homogenate samples from patients with adult periodontitis reacted with anti-human HSP 60 and bovine brain HSP 70 monoclonal antibodies. Antibodies which reacted with bacterial HSP were also found in a serum sample from a periodontitis patient. The present study suggests that HSPs are implicated in the human periodontal disease process.
Journal
-
- Japanese Journal of Microbiology
-
Japanese Journal of Microbiology 39 (5), 321-327, 1995
Center For Academic Publications Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1570291228151563520
-
- NII Article ID
- 130003484237
-
- ISSN
- 03855600
-
- Text Lang
- en
-
- Data Source
-
- CiNii Articles