Virulence in mice of Orientia tsutsugamushi isolated from patients in a new endemic area in Japan
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- Nagano Isao
- Department of Parasitology, Gifu University School of Medicine
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- Kasuya Shiro
- Department of Parasitology, Gifu University School of Medicine
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- Noda Nobuji
- Gifu Prefectural Health and Environment Research Center
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- Yamashita Teruo
- Department of Parasitology, Gifu University School of Medicine
書誌事項
- タイトル別名
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- Virulence in Mice of <i>Orientia tsutsugamushi</i> Isolated from Patients in a New Endemic Area in Japan
抄録
Four strains of Orientia tsutsugamushi (KN-1, KN-2, KN-3 and GJ-1) isolated from patients in an area of Gifu Prefecture, Japan, in which tsutsugamushi disease is newly endemic, were examined for their virulence in mice. Among these, KN-1 (identified as Kawasaki type), GJ-1 (identified as Kuroki type) and KN-2 strains were found to be non-lethal for BALB/c mice as well as CH3/HeJ mice, even with high doses (106×being the 50% mouse infectious dose). On the other hand, the KN-3 strain was found to be sufficiently virulent to kill BALB/c mice. Among the prototype strains (Gilliam, Karp and Kato), the Karp and Kato strains exhibited high virulence to mice, while the Gilliam strain killed only a susceptible strain of mouse. BALE/c mice infected with KN-1 and KN-2 strains showed significant splenomegaly and moderate ascites accumulation in the first week of infection, while these symptoms became prominent during the second week of infection using KN-3, Karp and Kato strains. After infection with the GJ-1 strain, these symptoms were not observed. Antibody responses induced by infections with highly virulent strains were lower than that with low or intermediate virulent strains.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 40 (10), 743-747, 1996
財団法人 学会誌刊行センター