Cooperative Anti-<i>Candida</i> Effects of Lactoferrin or Its Peptides in Combination with Azole Antifungal Agents
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- Wakabayashi Hiroyuki
- Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd.
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- Abe Shigeru
- Department of Microbiology and Immunology, Teikyo University School of Medicine
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- Okutomi Takafumi
- Department of Microbiology and Immunology, Teikyo University School of Medicine
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- Tansho Shigeru
- Department of Microbiology and Immunology, Teikyo University School of Medicine
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- Kawase Kouzou
- Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd.
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- Yamaguchi Hideyo
- Department of Microbiology and Immunology, Teikyo University School of Medicine
抄録
The effects of lactoferrin (LF), an antimicrobial protein secreted in body fluids, and its peptides in combination with azole antifungal agents were investigated by the micro-broth-dilution method in a study of Candida albicans. In the case of LF, its pepsin hydrolysate (LFhyd) or the LF-derived antimicrobial peptide Lactoferricin® B(LF-B), the concentrations required to inhibit the growth of Candida decreased in the presence of relatively low concentrations of clotrimazole (CTZ). The minimum inhibitory concentration (MIC) of all azole antifungal agents tested was reduced by 1/4-1/16 in the presence of a sub-MIC level of each of these LF-related substances. Polyene and fluoropyrimidine antifungal agents did not show such a combined effect with these LF-related substances. The anti-Candida activity of LF or LF-B in combination with CTZ was shown to be synergistic by checkerboard analysis. These results indicate that LF-related substances function cooperatively with azole antifungal agents against C. albicans.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 40 (11), 821-825, 1996
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1573387452894908160
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- NII論文ID
- 130003484316
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles