Transient Expression of CD20 Antigen (Pan B Cell Marker) in Activated Lymph Node T Cells

• Murayama Yuichi

  Institute of Basic Medical Sciences, University of Tsukuba

• Mukai Ryozaburo

  Tsukuba Primate Center for Medical Science, The National Institute of Health

• Sata Tetsutaro

  Laboratory of Pathology, AIDS Research Center, The National Institute of Health

• Matsunaga Satoko

  Institute of Basic Medical Sciences, University of Tsukuba

• Noguchi Atsuo

  Institute of Basic Medical Sciences, University of Tsukuba

• Yoshikawa Yasuhiro

  Tsukuba Primate Center for Medical Science, The National Institute of Health

Abstract

In contrast to the case of peripheral T cells, the surface expression of CD20 antigen and the expression of CD20 mRNA in monkey lymph node (LN) T cells underwent a noticeable increase when they were cultured with mitogen and interleukin-2 (IL-2). To confirm in vivo regulation of CD20 expression during the activation of LN T cells, we examined LNs derived from monkeys experimentally inoculated with simi-an immunodeficiency virus (SIV). Significant expression of CD20 antigen was detected in the T cells of the LNs at the stage of lymphadenopathy. These findings suggest that lymphocyte activation in the LNs induced expression of the CD20 molecule in some T cells.

Journal

• Japanese Journal of Microbiology

  Japanese Journal of Microbiology 40 (6), 467-471, 1996

  Center For Academic Publications Japan

Details

• CRID: 1571698603034645504
• NII Article ID: 130003484390
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00082708023?from=CiNii
• Text Lang: en
• Data Source:
  • CiNii Articles