Adherence of Peripheral Blood Leukocytes to Cytomegalovirus-Infected Fibroblasts

• Watanabe Masahiro

  Department of Pediatrics, Mie University School of Medicine

• Ito Masahiro

  Department of Pediatrics, Mie University School of Medicine

• Kamiya Hitoshi

  Department of Pediatrics, Mie National Hospital

• Sakurai Minoru

  Department of Pediatrics, Mie University School of Medicine

抄録

Peripheral blood monocytes and B cells adhered to cytomegalovirus (CMV)-infected fibroblasts, whereas T cells and polymorphonuclear leukocytes did not adhere to either CMV-infected or uninfected fibroblasts. When T cells were activated with anti-CD3 antibody, activated T cells demonstrated adherence and cytotoxicity to both CMV-infected and uninfected fibroblasts. Adherence of peripheral blood mononuclear cells (PBMC) and cytotoxicity mediated by adherent activated T cells were blocked by treatment of CMV-infected fibroblasts with anti-ICAM-1 antibody and by treatment of leukocytes with anti-LFA-1 antibody. These data suggest that an interaction of ICAM-1 and LFA-1 is responsible for the adherence of leukocytes and for adherent activated T cell-mediated cytotoxicity against CMV-infected fibroblasts.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 40 (7), 519-523, 1996

  Center For Academic Publications Japan

詳細情報

• CRID: 1574231877825026816
• NII論文ID: 130003484397
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00082794422?from=CiNii
• 本文言語コード: en
• データソース種別:
  • CiNii Articles