Herpes Simplex Virus-Specific IgM, IgA and IgG Subclass Antibody Responses in Primary and Nonprimary Genital Herpes Patients
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- Hashido Madoka
- Department of Epidemiology, National Institute of Health
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- Kawana Takashi
- Department of Obstetrics and Gynecology, Tokyo University Branch Hospital
抄録
To clarify the humoral immunity in herpes simplex virus (HSV) infection, HSV specific IgM, IgA and IgG subclass antibody responses were studied in patients with genital herpes: 17 primary, 13 recurrent and 6 nonprimary first episode. A total of 181 serum samples serially collected from the patients, 5 per patient until 213 days after the onset of disease (on average), were analyzed by an enzyme-linked immunosorbent assay. IgG1, IgG3 and IgA were detected in all patients with primary and nonprimary infections, whereas IgG4 was detected in 74% of only those with nonprimary infections and IgG2 was detected in none. IgM was detected in 100% of the patients with primary infections, but also in 68% of those with nonprimary infections. IgA showed a peak similar to that of IgM in patients with primary infections. No significant difference was observed in the detection rate or pattern of antibody responses between the recurrent and nonprimary first episode infections, nor between the HSV-1 and HSV-2 infections. These findings may be useful to improve the diagnostic potential of HSV serology.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 41 (5), 415-420, 1997
Center For Academic Publications Japan
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詳細情報
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- CRID
- 1573387452895147008
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- NII論文ID
- 130003484518
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles