Complement Receptor Type 3 Plays an Important Role in Development of Protective Immunity to Primary and Secondary <i>Corynebacterium pseudotuberculosis</i> Infection in Mice

J-STAGE
  • Lan Dinh Thi Bich
    Department of Veterinary Microbiology, Obihiro University of Agriculture and Veterinary Medicine
  • Makino Sou-ichi
    Department of Veterinary Microbiology, Obihiro University of Agriculture and Veterinary Medicine
  • Shirahata Toshikazu
    Department of Veterinary Microbiology, Obihiro University of Agriculture and Veterinary Medicine
  • Yamada Manabu
    Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine
  • Nakane Akio
    Department of Bacteriology, Hirosaki University School of Medicine

抄録

The present study was performed to investigate the role of CR3, the type 3 complement receptor, in host defense against primary and secondary Corynebacterium (C.) pseudotuberculosis infection in mice. Treatment of mice with 5C6, an anti-CR3 monoclonal antibody (mAb), resulted in unrestricted multiplication of bacteria in the organs and dramatically increased mortalities of the infected mice. Histological examinations showed the inflammation, degeneration and necrosis of organs and revealed that the infection-enhancing effect of 5C6 mAb was associated with the failure of mice to focus mononuclear phagocytes at sites of bacterial multiplication. These results suggest that CR3 plays an important role in host defense against primary as well as secondary C. pseudotuberculosis infection in mice.

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