Functional Characteristics of Human Peripheral Blood α/βTCR+, CD4- and CD8- Double-Negative (DN) T Cells
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- Niehues Tim
- Department of Pediatrics, University of Düsseldorf
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- Eichelbauer Dirk
- Department of Transfusion Medicine, University of Düsseldorf
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- Schneider E. Marion
- Department of Transfusion Medicine, University of Düsseldorf
Abstract
The function of human peripheral blood α/βTCR positive, CD4- and CD8- double-negative T lymphocytes (DN cells) in vivo is not completely understood. The response of immunomagnetically isolated DN cells to PHA and anti-CD3 was compared to the response of single-positive (SP) CD4 and CD8 subsets. Proliferation of DN cells in response to PHA was largely independent of APC. This suggests activation requirements for DN cells that are different from SP cells. Upon activation, HLA-DR was found to be upregulated early on DN cells, and IL-4 and IL-10 were detected in the supernatants of DN cells. These observations in vitro could correspond with an immunoregulatory role of human DN cells in vivo.
Journal
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- Japanese Journal of Microbiology
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Japanese Journal of Microbiology 43 (2), 153-159, 1999
Center For Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1571698603035542016
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- NII Article ID
- 130003484677
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- ISSN
- 03855600
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- Text Lang
- en
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- Data Source
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- CiNii Articles