Effective Inhibition of <i>Candida albicans</i> Growth by the Combination of Murine Peritoneal Neutrophils and Activated Macrophages

  • Tansho Shigeru
    Department of Microbiology and Immunology, University of Teikyo School of Medicine
  • Abe Shigeru
    Department of Microbiology and Immunology, University of Teikyo School of Medicine
  • Tansho Tohru
    Department of Microbiology and Immunology, University of Teikyo School of Medicine
  • Yamaguchi Hideyo
    Department of Microbiology and Immunology, University of Teikyo School of Medicine

抄録

The effect of leukocytes on the anti-Candida activity of neutrophils was examined. Murine neutrophils which were purified from casein-induced peritoneal cells inhibited the mycelial growth of Candida albicans. This anti-Candida activity of neutrophils was augmented by the addition of spleen cells prepared from mice pretreated with bacterial lipopolysaccharide 3hr before, but not from non-treated mice. The population in the spleen cells, which enhanced the anti-Candida activity of neutrophils, was plastic-plate adherent, nylon-fiber columns adherent and anti-Mac-1 antigen-positive. These immunological profiles suggested that the enhancing cells are classified to splenic macrophages. Peritoneal-exudated macrophages from mice treated with lipopolysaccharide also augmented the anti-Candida activity of neutrophils. These results suggest that the anti-Candida activity of neutrophils may be upregulated by activated macrophages.

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