Effective Inhibition of <i>Candida albicans</i> Growth by the Combination of Murine Peritoneal Neutrophils and Activated Macrophages
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- Tansho Shigeru
- Department of Microbiology and Immunology, University of Teikyo School of Medicine
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- Abe Shigeru
- Department of Microbiology and Immunology, University of Teikyo School of Medicine
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- Tansho Tohru
- Department of Microbiology and Immunology, University of Teikyo School of Medicine
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- Yamaguchi Hideyo
- Department of Microbiology and Immunology, University of Teikyo School of Medicine
抄録
The effect of leukocytes on the anti-Candida activity of neutrophils was examined. Murine neutrophils which were purified from casein-induced peritoneal cells inhibited the mycelial growth of Candida albicans. This anti-Candida activity of neutrophils was augmented by the addition of spleen cells prepared from mice pretreated with bacterial lipopolysaccharide 3hr before, but not from non-treated mice. The population in the spleen cells, which enhanced the anti-Candida activity of neutrophils, was plastic-plate adherent, nylon-fiber columns adherent and anti-Mac-1 antigen-positive. These immunological profiles suggested that the enhancing cells are classified to splenic macrophages. Peritoneal-exudated macrophages from mice treated with lipopolysaccharide also augmented the anti-Candida activity of neutrophils. These results suggest that the anti-Candida activity of neutrophils may be upregulated by activated macrophages.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 43 (3), 235-240, 1999
Center For Academic Publications Japan
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詳細情報
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- CRID
- 1570291228152000256
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- NII論文ID
- 130003484689
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles