Role of <i>Toxoplasma gondii</i> HSP70 and <i>Toxoplasma gondii</i> HSP30/bag1 in Antibody Formation and Prophylactic Immunity in Mice Experimentally Infected with <i>Toxoplasma gondii</i>

J-STAGE
  • Mun Hye-Seong
    Department of Parasitology, Chiba University School of Medicine
  • Aosai Fumie
    Department of Parasitology, Chiba University School of Medicine
  • Yano Akihiko
    Department of Parasitology, Chiba University School of Medicine

抄録

Production of antibodies against Toxoplasma gondii (T. gondii)-derived stress proteins, T. gondii HSP70 (T.g.HSP70) and T.g.HSP30/bag1, in C57BL/6 and BALB/c mice perorally infected with cysts of the avirulent Fukaya strain of T. gondii was analyzed. Production of anti-T.g.HSP70 IgG antibodies was transient, whereas production of anti-T.g. HSP30/bag1 IgG antibodies persisted after infection in both C57BL/6 and BALB/c mice. C57BL/6 mice, a susceptible strain, predominantly produced IgG antibodies specific for T.g.HSP70, whereas BALB/c mice, a resistant strain, predominantly produced IgG antibodies specific for T.g.HSP30/bag1, after T. gondii infection. Immunization with rT.g.HSP30/bag1 enhanced, whereas immunization with rT.g.HSP70 reduced host protective immunity against T. gondii infection with a cyst-forming avirulent strain, Fukaya, and a virulent strain, RH.

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