Effect of Antibiotics, Levofloxacin and Fosfomycin, on a Mouse Model with <i>Escherichia coli</i> O157 Infection

J-STAGE
  • Isogai Emiko
    Department of Preventive Dentistry, Health Sciences University of Hokkaido
  • Isogai Hiroshi
    Division of Animal Experimentation, Sapporo Medical University
  • Hayashi Shunji
    Department of Microbiology, Jichi Medical University
  • Kubota Toru
    Deparmment of Microbiology, Sapporo Medical University
  • Kimura Koichi
    Deparmment of Microbiology, Sapporo Medical University
  • Fujii Nobuhiro
    Deparmment of Microbiology, Sapporo Medical University
  • Ohtani Tsuyoshi
    New Product Research Laboratories 1, Daiichi Pharmaceutial Co., Ltd., Tokyo R & D Center
  • Sato Kenichi
    New Product Research Laboratories 1, Daiichi Pharmaceutial Co., Ltd., Tokyo R & D Center

抄録

There have been some reservations about the treatment of enterohemorrhagic Escherichia coli (EHEC) infection with antibiotics to prevent the occurrence of hemolytic uremic syndrome (HUS). However, the administration of antimicrobial agents for EHEC infection is under discussion. Therefore, we used an experimental mouse model to assess the advantage/disadvantage of two major antibiotics, levofloxacin (LVFX) and fosfomycin (FOM). Germ-free IQI mice were inoculated with EHEC O157 strain EDL931 or #7. Bacteria colonized feces at 109-1010CFU/g, and Shiga toxins (STXs) were detected in the feces. From 1 day after infection, mice were assigned to LVFX (20mg/kg) once daily or FOM (400mg/kg) once daily. A significant decrease in overall mortality was observed after treatment of LVFX, with EHEC disappearing immediately from the feces of mice. FOM also reduced mortality for one strain, the STX level decreased gradually. LVFX exhibited higher therapeutic efficacy than FOM. Strain differences were observed in the model during the treatment.

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