Kinetics of Thyroxine and Triiodothyronine in a Case of Thyroxine-binding Globulin Deficiency with Hypothyroidism
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- SAKURADA TOSHIRO
- Department of Internal Medicine, Tohoku University School of Medicine
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- YAMAGUCHI TORU
- Department of Internal Medicine, Tohoku University School of Medicine
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- YOSHIDA KATSUMI
- Department of Internal Medicine, Tohoku University School of Medicine
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- YAMAMOTO MAKIKO
- Department of Internal Medicine, Tohoku University School of Medicine
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- ONODERA SEIJU
- Department of Internal Medicine, Tohoku University School of Medicine
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- SAITO SHINTARO
- Department of Internal Medicine, Tohoku University School of Medicine
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Kinetics of T3 and T4 were studied in a case of TBG deficiency with hypothyroidism. Serum total and free T4 of 35-year-old man were 0.6 μg/100ml and 0.54 ng/100ml, respectively. Serum total and free T3 were 18 ng/100ml and 74 pg/100ml, respectively. BMR was -27%. Thyroidal 24-hr uptake of 131I was 7%. Resin-sponge 131I-T3 uptake was 52%. Binding capacity of TBG was O. Binding capacities of TBPA measured by two different methods were 240 and 223 μg/100ml. The half-life of T4 was shortened, the T4 distribution space, turnover rate and clearance rate increased. Extrathyroidal organic iodine pool and degradation rate decreased. The half-life of T3 was slightly shortened, turnover rate, distribution space and clearance rate increased. Extrathyroidal T3 pool and degradation rate decreased. During the treatment with 75 μg/day of l-T3, the patient's complaints disappeared. When administration of l-T3 was switched to 400 μg/day of l-T4, elevated serum T3 remained higher than the preadministration level. His mother and a younger sister had decreased T4-binding capacity of TBG.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 112 (2), 133-140, 1974
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679216875392
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- NII論文ID
- 130003491883
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- NII書誌ID
- AA00863920
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- COI
- 1:STN:280:DyaE2c3ltFynsQ%3D%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 7672509
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- PubMed
- 4209107
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可