Pulmonary function tests in excised dog lungs with small airway obstruction by beads.

SUGIYAMA MASAHARU, SASAKI HIDETADA, INOUE HIROSHI, NAKAMURA MASAO, SASAKI TAKAO, TAKISHIMA TAMOTSU

doi:10.1620/tjem.143.197

Pulmonary function tests in excised dog lungs with small airway obstruction by beads.

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SUGIYAMA MASAHARU

First Department of Internal Medicine, Tohoku University School of Medicine
SASAKI HIDETADA

First Department of Internal Medicine, Tohoku University School of Medicine
INOUE HIROSHI

First Department of Internal Medicine, Tohoku University School of Medicine
NAKAMURA MASAO

First Department of Internal Medicine, Tohoku University School of Medicine
SASAKI TAKAO

First Department of Internal Medicine, Tohoku University School of Medicine
TAKISHIMA TAMOTSU

First Department of Internal Medicine, Tohoku University School of Medicine

抄録

SUGIYAMA, M., SASAKI, H., INOUE, H., NAKAMURA, M., SASAKI, T. and TAKISHIMA, T. Pulmonary Function Tests in Excised Dog Lungs with Small Airway Obstruction by Beads. Tohoku J. exp. Med., 1984, 143 (2), 197-204 -About 100 beads, 2mm in diameter were wedged into the small airways of excised dog lungs. Pulmonary function tests were performed in the lungs before and after the obstruction of the small airway with beads. Of the pulmonary function tests performed, lung pressure-volume curve, lung resistance-lung volume relationship, frequency dependency of dynamic compliance, closing volume, and N₂ multiwash-out curve did not show any significant alteration after small airway obstruction. Only the flow-volume curve at low lung volume showed any significant alteration. This suggests that the flow-volume curve is the most sensitive pulmonary function test in the detection of early obstructive impairment of the small airways.