Effects of d-, l- and dl-Chlorpheniramine on Dopamine and 3,4-Dihydroxyphenylacetic Acid Levels in the Regional Parts of Rat Brain.
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- SAKURAI EIICHI
- Department of Pharmaceutics I, Tohoku College of Pharmacy
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- YAMASAKI SEIJI
- Department of Pharmaceutics I, Tohoku College of Pharmacy
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- HIKICHI NOBORU
- Department of Pharmaceutics I, Tohoku College of Pharmacy
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- ONODERA KENJI
- Department of Pharmacology, Tohoku University School of Dentistry
抄録
SAKURAI, E., YAMASAKI, S., HIKICHI, N. and ONODERA, K. Effects of d-, l- and dl-Chlorpheniramine on Dopamine and 3, 4-Dihydroxyphenylacetic Acid Levels in the Regional Parts of Rat Brain. Tohoku J. Exp. Med., 1991, 163 (4), 239-244 -The purpose of this study was to further investigate the differences in the effects of optical isomers of chlorpheniramine (d-, l- and dl-forms) on the levels of dopamine (DA) and 3, 4-dihydroxyphenylacetic acid (DOPAC) in the regional parts of rat brain. After the intravenous administration of each form of chlorpheniramine at a dose of 20mg/kg, the DA and DOPAC levels were measured by HPLC system. Each form of chlorpheniramine is effective in reducing DOPAC, but not DA levels in the brain of rats. The degree of reducing DOPAC levels does not correlate with the antihistaminic potency of these drugs. Thus, the present results indicate that there is a lack of stereospecificity in reducing DOPAC levels, suggesting the lack of stereospecificity in inhibiting DA reuptake.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 163 (4), 239-244, 1991
東北ジャーナル刊行会