The Microvasculature of the Human Bone Marrow Correlated with the Distribution of Hematopoietic Cells. A Computer-Assisted Three-Dimensional Reconstruction Study.
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- NAITO KUMIKO
- Department of Pathology, The Research Institute for Tuberculosis and Cancer, Tohoku University Second Department of Internal Medicine, Tohoku University School of Medicine
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- TAMAHASHI NOBUAKI
- Cluster Core Institute of Biology
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- CHIBA TAMIHIKO
- Department of Pathology, The Research Institute for Tuberculosis and Cancer, Tohoku University
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- KANEDA KYOKO
- Second Department of Internal Medicine, Tohoku University School of Medicine
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- OKUDA MITSUTAKA
- Second Department of Internal Medicine, Tohoku University School of Medicine
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- ENDO KAZUYASU
- Second Department of Internal Medicine, Tohoku University School of Medicine
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- YOSHINAGA KAORU
- Second Department of Internal Medicine, Tohoku University School of Medicine
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- TAKAHASHI TOHRU
- Department of Pathology, The Research Institute for Tuberculosis and Cancer, Tohoku University
抄録
NAITO, K., TAMAHASHI, N., CHIBA, T., KANEDA, K., OKUDA, M., ENDO, K., YOSHINAGA, K. and TAKAHASHI, T. The Microvasculature of the Human Bone Marrow Correlated with the Distribution of Hematopoietic Cells. A Computer-Assisted Three-Dimensional Reconstruction Study. Tohoku J. Exp. Med., 1992, 166 (4), 439-450-Surgical specimens of ordinary bone marrow from eight patients were submitted to computer-assisted three-dimensional reconstruction from resin-embedded, semi-thin serial sections. This was undertaken with the aim of contributing to a better understanding of hematopoietic microenvironment by establishing the basic architecture of the bone marrow, particularly the microvasculature and its relation to the hematopoietic cell series. The basic vascular structure was found to consist of mutually intertwining sinuses and hematopoietic cords (or compartments), the latter with an arteriole running along the axis. This allowed to define the unitary structure of the bone marrow as a hematopoietic cord with a central arteriole and surrounded by sinuses. Here granulopoietic cells were distributed mostly along the wall of the central arteriole. Erythropoietic cells, located mainly around the sinus wall, proved to be forming a continuous network of cord instead of separate “islands” as usually assumed, justifying a designation of “erythroblastic cords”. Megakaryocytes were positioned in close vicinity to the sinus wall. These findings appear not only to be helpful in analyzing factors involved in the in vivo hematopoietis of man, but also to visualize the importance of structural studies of bone marrow.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 166 (4), 439-450, 1992
東北ジャーナル刊行会
