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- 神野 潤一郎
- Osato Internal Clinic of the Medical Department, Tohoku University
抄録
The whole result may be summarised as follows: Aicienyaes have the sedative and paralytic action on a tadpole and a mouse; especially a mouse is killed with a considerably large dose, displaying cramp always in the course of poisoning. It is probable that they cause the paralysis of central nervous system. Each lethal dose is 2.5 to 8.0 mg. per every gram-me of mouse's weight. It is perceived that there are remarkable differences as to the toxicity. Because in this experiment, a tadpole did not develope cramp even with a considerably large dose. In the seven days inject ex-periment, the local stimulative action ensures, and it is likely that tadpoles are killed with almost the same dose as lethal dose or the less excessive dose than lethal dose.<br> Oxygenation by the oxygen of an originater apparatus, which springs up out of the action of super-sonic wave for the purpose of chymificating drugs, is slight and out of question.<br> On the isolated toad's heart, the aldehydes increase the beat and the systole and dilatation of a heart with a small dose, but with a large dose they paralyze a heart, weaken the beat or stop it at the dilative stage. It seems that its active point is there in myocardiums. At a definite con- centration a heart becomes excited with paralytic action if washed out with fresh Ringer's solution.<br> As for hemolytic action, it is conspicuous at high concentrations, but not at small concentrations. The blood vessel of toad's hind leg, if al-dehydes act on it with a large dose, has the systolic effect exclusively and with a small dose they have the dilative effect to some extent, but not to any definite, remarkable extent.<br> On bacillus, with one exception of n-capronaldehyde, aldehydes effect the action of checking growth and the sterilization action at the concentra- tions of 0.1% to 0.01%.<br> H. M. Vernon has shown the relative toxicity of these aldehydes on a tortoise heart. Judging from his result, I expected that those aldehydes with which I made experiment should have considerably feeble toxicity. My result coincides with L. Lewin's conclusion that Aldehydes have a strong hypnotic action.<br> In short, these aldehydes have the narcotic action, though in different grades, and the hemolytic action, of which I made the experiment in a test-tube, and the action of checking the growth of bacilli and the steriliza-tion.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 52 (3-4), 361-371, 1950
東北ジャーナル刊行会