3-Deacetoxy-7-(α-amino-1-cyclohexenylacetamido)cephalosporanic acid(SCE-100),a ncw semisynthetic cephalosporin-2-Comparative in vitro antibacterial activities of SCE-100 and cephalexin(CEX)
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- YAMAZAKI TOSHIYUKI
- Central Research Division, Takeda Chemical Industries, Ltd.
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- TSUCHIYA KANJI
- Central Research Division, Takeda Chemical Industries, Ltd.
書誌事項
- タイトル別名
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- 3-Deacetoxy-7-(.ALPHA.-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100), a new semisynthetic cephalosporin. II. Comparative in vivo antibacterial activities of SCE-100 and cephalexin (CEX).
- 3 Deacetoxy 7 アルファ amino 1 cyclohexenyl
- COMPARATIVE <i>IN VIVO</i> ANTIBACTERIAL ACTIVITIES OF SCE-100 AND CEPHALEXIN (CEX)
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The protective activity of 3-deacetoxy-7-(α-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100) against experimental intraperitoneal infections in mice caused by several strains of Gram-positive and Gram-negative organisms, including penicillin resistant strains, was compared with that of cephalexin (CEX). Comparable protective effects by oral administration of SCE-100 and CEX were observed in mice infected with Gram-positive organisms, while in mice infected with Gram-negative organisms SCE-100 was less active than CEX. SCE-100 showed a protective effect in infections of mice with either penicillin G-resistant Staphylococcus aureus or ampicillin-resistant Escherichia coli. The oral ED50, of SCE-100 was similar to or slightly larger than the subcutaneous value.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 29 (5), 566-570, 1976
公益財団法人 日本感染症医薬品協会
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詳細情報 詳細情報について
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- CRID
- 1390001204153933568
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- NII論文ID
- 130003499204
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaE28XktFCjtb0%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 1709647
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- PubMed
- 1048101
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可