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- BODEY GERALD P.
- The Department of Developmental Therapeutics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute
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- WEAVER SUSANNE
- The Department of Developmental Therapeutics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute
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- PAN THERESA
- The Department of Developmental Therapeutics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute
抄録
The in vitroactivity of a new semi-synthetic penicillin, CP-35, 587, 3-(5-tetrazolyl) penam, was investigated against 496 clinical isolates of gram-negative bacilli and 113 clinical isolates of gram-positive cocci. All of the gram-positive cocci were sensitive to CP-35, 587 except penicillin G resistant isolates of Staphylococcus aureus. This antibiotic inhibited a majority of isolates of Escherichia coli, Klebsiellaspp. and Proteus mirabilisat a concentration of 6.25 μg/ml. Also, approximately half of the isolates of Serratia marcescensand Enterobacterspp. were inhibited at a concentration of 12.5μg/ml. CP-35, 587 was inactive when high concentrations of organisms were used as inocula. CP-35, 587 was more active than mezlocillin, azlocillin, amoxicillin, ticarcillin and carbenicillin against isolates of K. pneumoniae, but other<br>penicillins were more active than CP-35, 587 against other species of gram-negative bacilli.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 30 (9), 724-729, 1977
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