Studies on new dehydropeptidase inhibitors. III. Biological properties of WS1358A1.

DOI 被引用文献1件
  • HASHIMOTO SEIJI
    Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • MURAI HIDETSUGU
    Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • NITTA KUMIKO
    Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • FUJIE AKIHIKO
    Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • OKUHARA MASAKUNI
    Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • KOHSAKA MASANOBU
    Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • IMANAKA HIROSHI
    Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

書誌事項

タイトル別名
  • III. BIOLOGICAL PROPERTIES OF WS1358A1

抄録

WS1358A1, a novel inhibitor of renal dehydropeptidase (DHP), augmented the urinary recovery of a carbapenem antibiotic imipenem and improved its protective effect in experimental infections when simultaneously administered to mice with the antibiotic.<br> WS1358A1 was a competitive DHP inhibitor with a Ki value of 1.6×10-7M.

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詳細情報 詳細情報について

  • CRID
    1390282679122161408
  • NII論文ID
    130003501798
  • DOI
    10.7164/antibiotics.43.281
  • ISSN
    18811469
    00218820
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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