Antibiotics from basidiomycetes XLI. Clavicoronic acid, a novel inhibitor of reverse transcriptases from Clavicorona pyxidata (Pers. ex Fr.) Doty.

• ERKEL GERHARD

  LB Biotechnologie der Universität

• ANKE TIMM

  LB Biotechnologie der Universität

• GIMENEZ ALBERTO

  Institut für Organische Chemie und Biochemie der Universität

• STEGLICH WOLFGANG

  Institut für Organische Chemie und Biochemie der Universität

書誌事項

タイトル別名

• CLAVICORONIC ACID, A NOVEL INHIBITOR OF REVERSE TRANSCRIPTASES FROM <i>Clavicorona pyxidata</i> (PERS. EX FR.) DOTY

抄録

A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 μM) and Moloney murine leukemia virus (Ki 68μM) reverse transcriptases. In permeabilized cells and isolated nucleic DNA- and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 45 (1), 29-37, 1992

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390001204146612480
• NII論文ID: 130003502086
• DOI: 10.7164/antibiotics.45.29
• COI: 1:CAS:528:DyaK38XhsVOlur0%3D
• ISSN: 18811469
• ISSN: 00218820
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可