Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation and biological activity.
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- OMURA SATOSHI
- Research Center for Biological Function, The Kitasato Institute
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- PYL DIDIER VAN DER
- Research Center for Biological Function, The Kitasato Institute Present address: Rhone-Poulenc Rorer, Centre de Recherche de Vitry
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- INOKOSHI JUNJI
- Research Center for Biological Function, The Kitasato Institute
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- TAKAHASHI YOKO
- Research Center for Biological Function, The Kitasato Institute
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- TAKESHIMA HIDEO
- Research Center for Biological Function, The Kitasato Institute
書誌事項
- タイトル別名
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- I. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY
抄録
Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp. OH-4652. These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex LH-20 chromatography and reverse phase HPLC. Among these, pepticinnamin C showed the most potent inhibition (IC50-100nM).
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 46 (2), 222-228, 1993
公益財団法人 日本感染症医薬品協会