Novel C-2 Substituted Carbapenem Derivatives Part III. Synthesis and Biological Activity of 2-(Functionalised Ethenyl, Oxyiminomethyl and .ALPHA.-(Hydroxy)benzyl)-Carbapenems.

• CLEAR NICOLA J. C.

  SmithKline Beecham Pharmaceuticals

• VIES JOHN S. DA

  SmithKline Beecham Pharmaceuticals

• EGLINGTON A. JOHN

  SmithKline Beecham Pharmaceuticals

• FELL STEPHEN C. M.

  SmithKline Beecham Pharmaceuticals

• HINKS JEREMY D.

  SmithKline Beecham Pharmaceuticals Present address: University of Southampton

• HIRD NICHOLAS W.

  SmithKline Beecham Pharmaceuticals

• HUNT ERIC

  SmithKline Beecham Pharmaceuticals

• MOSS STEPHEN F.

  SmithKline Beecham Pharmaceuticals

• PEARSON MICHAEL J.

  SmithKline Beecham Pharmaceuticals

書誌事項

タイトル別名

• Part III. Synthesis and Biological Activity of 2-(Functionalised Ethenyl, Oxyiminomethyl and α-[Hydroxy]benzyl)-Carbapenems

抄録

The synthesis, antibacterial activity and stability to human dehydropeptidase-1 (DHP-1) of three small series of carbapenems carrying carbon-linked substituents at C-2 are described. C-2 Ethenyl carbapenems showed moderate antibacterial activity but poor stability to DHP-1. C-2 Oxyiminomethyl carbapenems demonstrated variable activity and stability. C-2 α-(Hydroxy)benzyl carbapenems were the most promising and showed good potency and DHP-1 stability.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 50 (3), 237-245, 1997

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390282679127036800
• NII論文ID: 130003503274
• DOI: 10.7164/antibiotics.50.237
• COI: 1:CAS:528:DyaK2sXisFentbg%3D
• ISSN: 18811469
• ISSN: 00218820
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可