FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties.
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- FUJIE AKIHIKO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- IWAMOTO TOSHIRO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- MURAMATSU HIDEYUKI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- OKUDAIRA TERUMI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- NITTA KUMIKO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- NAKANISHI TOMOKO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- SAKAMOTO KAZUTOSHI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- HORI YASUHIRO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- HINO MOTOHIRO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- HASHIMOTO SEIJI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- OKUHARA MASAKUNI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
書誌事項
- タイトル別名
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- I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties
抄録
FR901469 is a novel antifungal antibiotic produced by an unidentified fungus No.11243. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatography, and lyophilization. FR901469 is a white powder which melts at 182-187°C and possesses the molecular formula C71H116N14O23. This compound has good water solubility. FR901469 inhibited the activity of 1, 3-β-glucan synthase from Candida albicans with an IC50 value of 0.05μg/ml, and displayed greater inhibitory activity than other 1, 3-β-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 53 (9), 912-919, 2000
公益財団法人 日本感染症医薬品協会
