Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523.
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- FUJINE KIYOTAKA
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- TANAKA MIHO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- OHSUMI KEISUKE
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- HASHIMOTO MICHIZANE
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- TAKASE SHIGEHIRO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- UEDA HIROTSUGU
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- HINO MOTOHIRO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- FUJII TAKASHI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
書誌事項
- タイトル別名
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- I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523
抄録
Novel immunosuppressive agents, FR252921, FR252922 and FR256523 were isolated from the cultured broth of a bacterial strain No. 408813. The strain was identified Pseudomonas fluorescens from morphological and physiological characteristics.<br>FR252921, FR252922 and FR256523, novel compounds containing macrolactone ring, showed immunosuppressive activity against murine splenocyte proliferation stimulated with lipopolysaccharide (LPS) or anti-CD3 mAb in vitro.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 56 (2), 55-61, 2003
公益財団法人 日本感染症医薬品協会
