Archazolids, New Cytotoxic Macrolactones from Archangium gephyra (Myxobacteria) Production, Isolation, Physico-chemical and Biological Properties
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- SASSE FLORENZ
- GBF, German Research Centre for Biotechnology, Department Natural Product Biology
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- STEINMETZ HEINRICH
- GBF, German Research Centre for Biotechnology, Department Natural Product Chemistry
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- HÖFLE GERHARD
- GBF, German Research Centre for Biotechnology, Department Natural Product Chemistry
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- REICHENBACH HANS
- GBF, German Research Centre for Biotechnology, Department Natural Product Biology
書誌事項
- タイトル別名
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- Production, Isolation, Physico-chemical and Biological Properties
抄録
Novel cytotoxic compounds, archazolid A and B, were isolated from the culture broth of strains of the myxobacteria Archangium gephyra and Cystobacter sp. Archazolids consist of a macrocyclic lactone ring with a thiazole side chain and showed high activity against mammalian cells. The IC50 values with different cell lines ranged from 0.1 to 1ng/ml. An incubation of PtK2 potoroo cells with archazolid A (5ng/ml) led to the formation of vacuoles in the ER, a phenomenon that is typical for inhibitors of V-ATPases, like concanamycin and bafilomycin. We therefore assume that archazolid is an inhibitor of the V-ATPase of higher cells.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 56 (6), 520-525, 2003
公益財団法人 日本感染症医薬品協会
