核酸の生合成に関する研究(第1報)ボリヌクレオタイドプリン体の先駆物質としての4-アミノイミダゾールカルボキサミドの役割について

• 野口 照久

書誌事項

タイトル別名

• Studies on the Biosynthesis of Nucleic Acids. I. On the Role of 4-Aminoimidazole-5-carboxamide as a Precursor of Polynucleotide Purines

抄録

By employing 4-aminoimidazole[4-¹⁴C]-5-carboxamide, formate-¹⁴C, and ³²P, the role of the carboxamide as a precursor of polynucleotide purines was examined. The in vitro incorporation of the labeled carboxamide into polynucleotide adenine and guanine was found by rat liver slices and by cell-free system. The specific activity was about 2∼5 times higher in adenine than in guanine. In the case of regenerating liver, generally higher specific activity was observed than in the case of normal liver. The stimulatory effect of the non-labeled carboxamide in the course of the incorporation of formate-¹⁴C and ³²P into polynucleotides was demonstrated.

収録刊行物

• Pharmaceutical Bulletin

  Pharmaceutical Bulletin 4 (2), 92-96, 1956

  公益社団法人 日本薬学会

キーワード

• General Medicine

詳細情報

• CRID: 1390282680235587072
• NII論文ID: 130003549079
• DOI: 10.1248/cpb1953.4.92
• COI: 1:STN:280:DyaG28%2FovVSrtQ%3D%3D
• ISSN: 18811345
• ISSN: 03699471
• PubMed: 13335470
• Web Site: https://www.jstage.jst.go.jp/article/cpb1953/4/2/4_2_92/_pdf
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• 抄録ライセンスフラグ: 使用不可