Inoculation Experiment of Leprosy Bacilli with Liquid Paraffin and Subcutaneous Fat of a Human Being or of a Fowl.

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  • SATO Saburo
    Kosankinbyo-Kenkyusho (Research Institute for Tuberculosis and Leprosy), Tohoku University

Abstract

1) If suspensions of leprosy bacilli (human and rat) in liquid paraffin or subcutaneous fat oil of a human being or a fowl are inoculated at least twice into the pectoral muscles at certain intervals, manifest tumor-like granulomas were produced in the viscera, especially in the pericard, epicard, apex of the heart, peri- and interlobar capsule of the liver and mesentery. Although similar lesions are produced by repeated injections of a suspension of bacilli in saline solution only, results obtained by this method were surer and more remarkable.<br>2) Skin allergy to lepromin (1:20 emulsion of leproma in saline solution) was provoked in some fowls, injected with an oil suspension of bacilli, while it remained always negative even in fowls, inoculated with a suspension of bacilli in a saline solution ten times and oftener repeatedly.<br>Skin allergy to human leprosy bacilli is obtained only in fowls, inoculated with the same bacilli, and that to rat leprosy bacilli produced only in fowls and not in rats, treated with rat leprosy bacilli. And tuberculin skin allergy is not produced in all of the experimented fowls.

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