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- KOBAYASHI Yoshito
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- URAGUCHI Kenji
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- SAKAI Fuminori
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- TATSUNO Takashi
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- TSUKIOKA Michio
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- NOGUCHI Yasuhiro
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- TSUNODA Hiroshi
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- MIYAKE Masashi
- Department of Pathology, Faculty of Medicine, University of Tokyo
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- SAITO Mamoru
- Department of Pathology, Faculty of Medicine, University of Tokyo
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- ENOMOTO Makoto
- Department of Pathology, Faculty of Medicine, University of Tokyo
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- SHIKATA Toshio
- Department of Pathology, Faculty of Medicine, University of Tokyo
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- ISHIKO Toshitaka
- Department of Pathology, Faculty of Medicine, University of Tokyo
書誌事項
- タイトル別名
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- Experimental Verification of Primary Hepatic Carcinoma of Rats by Long Term Feeding with the Fungus-growing Rice
抄録
Our toxicological researches made plain, as previously reported, that the yellowed rice inoculated with P. islandicum Sopp is capable of inducing acute and subacute liver injuries and chronic diseases like liver cirrhosis and might possibly cause malignant hepatoma. With the aim, therefore, to ascertain whether the hepatoma can be induced or not, since 1957 we have fed 3 groups of rats, 30 each, though 3 in A group, 8 in B group and 4 in C group still survive as of the 650th day. The following results have so far been obtained.<br>1. In A group fed with the moldy rice only, the primary hepatic carcinoma was found in the rats dying on 548th and 553rd day. In these cases, though no metastasis was found in other organs than the liver, there were observed the infiltration of the hepatoma cells into the capsule of liver or the intrahepatic metastasis, i.e. the thrombus of hepatoma cells. Moreover the sarcomatous tumor was found in the liver of 3 cases dying on 548th, 569th, and 622nd day.<br>2. Beside the above hepatoma, were found in the most cases, as usually observed hitherto, the fibrosis, the proliferation of small bile ducts including cholangiofibrosis and the nodular hyperplasia of liver cells, except the liver cirrhosis.<br>3. In B group fed with the DAB-added moldy rice and in C group with DAB without the moldy rice, 11 cases and 6 cases each had the primary hepatic carcinoma to die between 248th-379th day in the former and between 356th-396th day in the latter, indicating that the moldy rice is capable of shortening the lifetime in case of DAB only. The metastasis of the hepatic carcinoma was found in the lung artery of one case of B group. Moreover the sarcoma was observed to concur with the hepatic carcinoma on the case each of the both groups.
収録刊行物
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- Proceedings of the Japan Academy
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Proceedings of the Japan Academy 35 (8), 501-506, 1959
日本学士院
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詳細情報 詳細情報について
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- CRID
- 1390282680088157312
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- NII論文ID
- 130003552819
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- ISSN
- 00214280
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可