涙液中薬物濃度測定の有用性　　涙液中薬物動態に関する速度論的研究

• 佐藤 眞治

  新潟薬科大学薬剤学教室

• 北河 修治

  新潟薬科大学薬剤学教室

• 中島 正晴

  県立食品総合研究所

• 嶋田 健次

  新潟薬科大学分析化学

• 本多 彰

  宮本病院

• 宮崎 浩

  新潟薬科大学薬物動態学

書誌事項

タイトル別名

• Assessment of Tear Concentrations on TDM. Pharmacokinetic Studies of Theophylline and Valproic Acid in Plasma, Cerebrospinal Fluid and Tear.
• Pharmacokinetic Studies of Theophylline and Valproic Acid in Plasma, Cerebrospinal Fluid and Tear
• ―涙液中薬物動態に関する速度論的研究―

抄録

It has been recognized that the pharmacologic effect and the adverse reaction of a drug are closely related to the concentration of its free form at the site of action. The measurement of this concentration is very important to manage the optimal therapeutic response with the minimum adverse effects but it is practically impossible. The cerebrospinal fluid (CSF) concentration of a drug which acts on the central nervous systems is believe to be instantaneously equilibrated with its concentration at the site of action. The tear concentration of a drug reflects not only its plasma free concentration but also its CSF concentration. The individualization of the dosage regimen become to be very important for the drugs with narrow therapeutic windows such as anticonvulsants and antiasthmatics. The purpose of the present study is to develop a pharmacokinetic model for theophylline and valproic acid in tear and CSF, and to examine whether their CSF concentrations can be predicted by their tear concentrations in patients. The time courses of theophylline and valproic acid concentrations in guinea pig CSF and tear were similar to those of their free concentrations in plasma, and could be described by a basic physiological model in which their CSF and tear compartments are independently connected with their plasma compartments (free drugs) based on the apparent diffusion constants. The CSF concentrations of theophylline at the steady states of both guinea pigs and patients could be predicted by its tear concentrations using the resulting pharmacokinetic parameters. The measurement of the drug concentrations in tear which can be collected non-invasively might be a very useful method for individual dosage regiment of these drugs in patients.

収録刊行物

• 薬物動態

  薬物動態 15 (2), 189-195, 2000

  日本薬物動態学会

キーワード

• Tear
• Cerebrospinal fluid
• Theophylline
• Valproic acid
• Guinea pig
• Patient
• Pharmacokinetics

詳細情報

• CRID: 1390001204670263680
• NII論文ID: 10008416133
• NII書誌ID: AN10144117
• DOI: 10.2133/dmpk.15.189
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/15/2/15_2_189/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000213262
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可