右眼球突出を初発症状とした腸間膜原発悪性リンパ腫の1例

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  • A Case of Malignant Lymphoma of the Mesenterium Presented with Right Exophthalmos.

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We have encountered a case of malignant lymphoma of the mesenterium presented with right exophthalmos.<br> A 52-year-old woman noticed right exophthalmos two months earlier. Computed tomography (CT) revealed a right orbital tumor and an upper abdominal tumor 8cm in diameter. The abdominal tumor was revealed as hot area of RI uptake on a Ga67 scintigram, and was considered as malignant tumor. On January 5 1998, she had severe, burning epigastric pain, abdominal distension and vomiting due to an enlargement of the abdominal tumor. Emergency operation was performed and about 50cm jejunum with the tumor was resected. Histological examination confirmed malignant lymphoma (diffuse, large, B-cell type). After the operation, systemic chemotherapy with 6 cycles of CHOP and radiotherapy for metastatic bone tumor at 30Gy were given and a transient remission was attained. However, 9 month after the initial operation, the patient's condition took a downhill course and died of multiple liver metastasis.<br> It is extremely difficult to diagnose malignant lymphoma of the mesenterium. When the tumor is detected, many cases are of far advanced. Early diagnosis and systemic radiochemotherapy should be adapted to improve the poor prognosis of this disease. In this case, we had to operate on because the patient had developed intestinal obstruction. However, with preoperative histologic study and clinical staging, less invasive therapeutic method might be selected.

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