ガンシクロビルにて改善したウイルス脳炎の1例

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タイトル別名
  • Viral encephalitis successfully treated with ganciclovir.

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A 57-year-old woman was admitted to our hospital with fever and lethargy. Cerebrospinal fluid (CSF) examination revealed pleocytosis and increased protein content. Immunological testing was positive for anti-herpes simplexvirus antibody and anti-cytomegalovirus antibody in each titer. Viral encephalitis was diagnosed and the patientwas initially treated with acyclovir, but was completely unresponsive to the drug. Since acyclovir was ineffective, the patient was switched to ganciclovir. This was followed by fever reduction and a decrease in CSF cell count. Theetiology of the encephalitis in this case was thought to be infection by acyclovir-resistant herpes simplex virus, ormixed infection by acyclovir-resistant herpes simplex virus and cytomegalovirus. When acyclovir is ineffective inviral encephalitis, ganciclovir may be the treatment of choice.

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