Blood-brain barrier dysfunction in the elderly patients with the progressive subcortical vascular encephalopathy.

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  • 老年者のＰｒｏｇｒｅｓｓｉｖｅ　ｓｕｂｃｏｒｔｉｃａｌ　ｖａｓｃｕｌａｒ　ｅｎｃｅｐｈａｌｏｐａｔｈｙにおける脳血管透過性異常について

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Abstract

We examined the csf/serum ratios for albumin and IgG in the elderly patients with chronic cerebral infarction to know the rule of the blood-brain barrier function in the progressive subcortical vascular encephalopathy (PSVE).<BR>17 patients with PSVE, 9 patients with cerebral infarct in the territory of cortical arteries, and 5 controls were examined.<BR>Patients with PSVE showed significantly (p<0.05) elevated csf/serum ratios for albumin and IgG compared to them of the other groups.<BR>However, there was no significant difference in csf/serum ratios for albumin and IgG between the group of patients with cerebral cortical infarct and the group of controls.<BR>There was also no significant difference in IgG index among 3 groups.<BR>These results showed that there was an increase of the permeability of the cerebral blood vessels in PSVE..<BR>We need to consider that they could have some rule on a genesis of the brain damage in PSVE.

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