抗カルジオリピン抗体陽性の特発性血小板減少性紫班病に脳梗塞を合併した１症例

• 前田 喜一

  名古屋第一赤十字病院神経内科 国保東栄病院内科 M.D.

• 村山 知行

  名古屋第一赤十字病院神経内科 M.D.

• 真野 和夫

  名古屋第一赤十字病院神経内科 M.D.

• 渡邊 英夫

  名古屋第一赤十字病院神経内科 M.D.

• 杉原 卓朗

  同血液内科 M.D.

書誌事項

タイトル別名

• A case of cerebral infarction associated with idiopathic thrombocytopenic purpura and anti-cardiolipin antibody.

抄録

A 54-year-old man was admitted to our hospital complaining of clumsiness of right hand and dysarthria. Neurological examination revealed moderate weakness of the right upper extremities with mild sensory aphasia, agraphia, and alexia. The CT scan of the brain disclosed a low-density area around the left angular gyrus, and the cerebral angiography showed moderate stenosis of M1 portion of the left middle cerebral artery. The diagnosis of brain infarction was made.<BR>No hemorrhagic tendency was clinically observed, but thrombocytepenia with normal bone marrow persisted. Platelet associated IgG was increased so that the association of idiopathic thrombocytepenic purpura (ITP) was diagnosed.<BR>The platelet aggregation induced by ADP, arachidonic acid, and epinephrin was all decreased. The serologic test for syphilis was false-positive and serum anti-cardiolipin antibody was found. Other abnormalities in coagulation and fibrinolysis and autoantibodies could not be detected.<BR>We speculate that anti-cardiolipin antibody contributed to cause cerebral infarction through immunological process in the circumstances of thrombocytopenia due to ITP.

収録刊行物

• 脳卒中

  脳卒中 14 (4), 402-408, 1992

  一般社団法人 日本脳卒中学会

キーワード

• idiopahic thrombocytepenic purpura
• cerebral infarction
• anticardiolipin antibody
• platelet aggregation

詳細情報

• CRID: 1390282679616695424
• NII論文ID: 130003630992
• DOI: 10.3995/jstroke.14.402
• ISSN: 18831923
• ISSN: 09120726
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可