抗血小板薬連続内服による血小板凝集能の経時的変動　　粒子計測型血小板凝集能測定装置（ＡＧ‐１０）による検討

DOI 被引用文献1件 参考文献22件

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  • Effects of daily antiplatelet medication for 2 weeks on platelet aggregability measured by a particle counting method using laser scattering and by the optical method in cerebral thrombosis patients.
  • 粒子計測型血小板凝集能測定装置 (AG-10) による検討

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We examined the effects of aspirin and ticlopidine on the platelet aggregability during daily antiplatelet medication for 2 weeks. Eighteen post-thrombotic stroke patients were studied : 10 patients received 330 mg aspirin once a day, and 8 patients received 100 mg ticlopidine twice a day. The platelet aggregability was measured by the laser scattering method (AG-10, Kowa Ltd.) and by the opital method. With the laser scattering method, we were able to detect small, medium, and large size particles of aggregates. The aggregation of platelet-rich plasma (PRP) was estimated after stimulation with collagen (1, and 2 μg/ml) and ADP (0.5, and 5.0 μM) before, and at 1, 2, 4, 7, and 14 days after antiplatelet medication. In addition, the effects of aspirin on the platelet aggregability were measured before and at 1, 2, 3, 4, 6, and 12 hours after the administration. Aspiria significantly reduced (p<0.05) both the platelet aggregability by the optical method and the formation of medium and large platelet aggregates induced by 1 μg/ml collagen at the 1st day after antiplatelet medication, but had little effect on the formation of small platelet aggregates. Furthermore, aspirin began to reduce significantly (p<0.05) after the 1st hour both the platelet aggregability and the formation of large platelet aggregates induced by 2 μg/ml collagen. Ticlopidine revealed no significant reduction in both the platelet aggregability and the formation of all platelet aggregates induced by 0.5, and 5.0 μM ADP on the 1st day, but the aggregability by the optical method was significantly reduced (p<0.05) on the 2nd day, and particularly on the 4th day. The above results suggest that the antiplatelet effects of aspirin and ticlopidine may have different kinetics.

収録刊行物

  • 脳卒中

    脳卒中 19 (5), 340-348, 1997

    一般社団法人 日本脳卒中学会

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