マウスの胎児の奇形および胚死亡に対する温熱の影響

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  • Malformation and Embryonic Death in ICR Mice after Mild Hyperthermia.

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Experimental studies on mice have made it clear that embryos are more sensitive to radiation during organogenesis than other prenatal periods. However, the teratogenic effects of hyperthemia at organogenesis in mice have yet to be described. The organogenesis stage is the most important from the viewpoint of non ionizing protection. Many physical and chemical agents in the environment can affect an embryo. Fetal deaths were classified as preimplantation, embryonic and fetal. For preimplantation deaths, all the treatment groups differed significantly from the control group and the Sham control group of implantation (P<0.001). Regarding teratogenesis, exencephaly, cleft palate, abdominal hernia, anomalies of tail, and so on were observed in the hyperthermia group treated at 192 hours post-conception (192 hpc). There was no temperature dependence though fetal body weight at the embryonic age of 18 days differed slightly but significantly between the hyperthermia and control groups. There was a difference based on gender, but this was thought to be due to physiological sexuality, not temperature.<BR>Pregnant ICR mice at 192 hpc, the organogenesis stage of embryonic development, were treated with whole body hyperthemia of 37, 38, 39, 40, 41, and 42°C for 10 min. Embryonic mortality in the mice treated at the stage of organogenesis was higher than in the mice treated at the fetal stage. Many types of external gross malformations such as exencephaly, cleft palate and anophthalmia were observed in the live fetuses mice treated at 38.5°C. However, no malformations were observed in mice treated below 38°C. It is believed that embryos during hyperthemia are not susceptible to teratogens such as radiation and chemical agents. In this study, the sensitivity to external malformations of the fetuses of mice subjected to hyperthemia during Organogenesis was examined.

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