ラット脳皮質に分布する微小血管周囲細胞（Ｆ．Ｇ．Ｐ．）の経年変化に対するビタミンＥの影響

DOI Web Site PubMed 被引用文献1件

書誌事項

タイトル別名
  • The Effect of Vitamin E on Aging of Granular Perithelial Cell in Cerebral Fine Vessels of Rat
  • ラット ノウ ヒシツ ニ ブンプスル ビショウ ケッカン シュウイ サイボウ

この論文をさがす

抄録

It has been assumed that vitamin E suppressed an increase of superoxides in tissues and organs in aging process. The authors intended to clarify the relationship between the aging of “fluorescent granular perithelium (F.G.P.)” and vitamin E in this study. By the authors' investigation, the granular perithelial cells were distributed in cerebral fine vessels, especially, in bifurcating regions of them, and contained large fluorescent inclusion bodies. The F.G.P. changed in shape and contents in aging process.<br>In order to investigate the effect of vitamin E on F.G.P., two groups of rats fed with vitamin E deficient or vitamin E rich (Juvela-nicotinate) chow were studied at light and electron microscopical levels.<br>According to the previous reports of the authors, it had be ascertained that the granular perithelial cells could incorporate efficiently exogenous substances (horseradish peroxidase, trypan blue and ferritin), if administered intraventricularly, and were facilitated in the uptake capacity with administration of vasopressin. Subsequently, the F.G.P. were interpreted as a kind of scavenger cells in a central nervous tissue. If they were fallen into a degeneration, waste products in a central nervous tissue would be piled up without any degradation.<br>In this study, the perithelial cells in rats which were fed with vitamin E deficient chow for eight to ten months tended to take a regressive change. That is, in general, the contrast in electron opacity of cytoplasmic organelles of F.G.P. became low and especially, limiting membranes of intracellular granules became obscure. Concomitantly, mitochondria were swollen and their cristae were arranged irregularly. Histochemically, acid phosphatase activity was hsgh and was detected through the cytoplasm. Occasionally, degenerating F.G.P. with dark matrices appeared between endothelium and nervous tissues. Further, it was also noticeable that after the degeneration of perithelial cells, collagen fibers came out in the intercellular spaces between degenerating perithelial cells and nervous tissue.<br>On the contrary, the perithelial cells in rats which were fed with the chow containing Juvela-nicotinate did not reveal distinct regressive signs but some exceptions. Intracellular granules changed in profiles and contents, and occasionally took honeycomb forms, but the other signs for regressive changes did not appear in cytoplasmic organelles.<br>Therefore, the perithelial cells in rats fed with vitamin E deficient chow for a long period tended to go down in their function, and the regression could induce a disorder of an uptake capacity for metabolic wastes in a central nervous tissue, and enhance a fibrosis around cerebral fine vessels.<br>In other words, it could be said that vitamin E was useful for maintaining a function and morphology of the granular perithelial cells in aging process.

収録刊行物

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ