Chronic Administration of Lisuride Hydrogen Maleate Increases Muscarinic Acetylcholine Receptor Binding in Aged Rat Brain.

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  • Takayama Haruhiko
    Third Department of Internal Medicine, Okayama University Medical School
  • Asanuma Masato
    Institute for Neurobiology, Okayama University Medical School
  • Mizukawa Kiminao
    Department of Anatomy, Okayama University Medical School
  • Hirata Hiroshi
    Third Department of Internal Medicine, Okayama University Medical School
  • Sato Hirohiko
    Third Department of Internal Medicine, Okayama University Medical School
  • Ota Zensuke
    Third Department of Internal Medicine, Okayama University Medical School
  • Ogawa Norio
    Institute for Neurobiology, Okayama University Medical School

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Other Title
  • Ｌｉｓｕｒｉｄｅ　ｈｙｄｒｏｇｅｎ　ｍａｌｅａｔｅ投与による老齢ラット脳ムスカリン性アセチルコリンレセプターの改善　定量的レセプター・オートラジオグラフィー法による検討
  • Lisuride hydrogen maleate トウヨ ニ ヨル ロウレイ
  • 定量的レセプター・オートラジオグラフィー法による検討

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Abstract

Changes in the distribution and densities of muscarinic acetylcholine receptors (mACh-R) in young adult and aged rat brain, and the effects of chronic administration of lisuride hydrogen maleate (lisuride) on these changes were studied by in vitro quantitative autoradiography of [3H] quinuclidinyl benzilate binding. mACh-R was relatively higher in the striatum, hippocampus and cerebral cortex in the young adult rats. In contrast, mACh-R binding was markedly reduced in the striatum, accumbens nucleus, amygdaloid nucleus and frontal cerebral cortex of aged rats compared to young adult rats. However, chronic administration of lisuride significantly increased mACh-R binding in the parietal cerebral cortex as well as in the above-mentioned regions in aged rats. This lisuride-induced increase in mACh-R of aged rat brain is considered to have important implications concerning the mechanism of therapeutic efficacy of lisuride.

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