Ｃａｎｄｉｄａ　ａｌｂｉｃａｎｓ免疫モルモット由来Ｔｒａｎｓｆｅｒ　ｆａｃｔｏｒ　Ｉ　　ｉｎ　ｖｉｖｏ活性

• 近藤 譲

  名古屋大学医学部附属病態制御研究施設医真菌研究部門

書誌事項

タイトル別名

• Transfer of cell-mediated immunity by dialyzable extracts of lymphoid cells from guinea pigs immunized with Candida albicans: I. In vivo activity.
• I. <i>In vivo</i> Activity
• I. <i>In vivo</i> 活性

抄録

Transfer factor was prepared from the spleens and lymph nodes of guinea pigs immunized with killed Candida albicans. The supernatant of lysate when the lymphoid cell was disrupted by freezing and thawing was applied to ultrafiltration by a diaflo membrane of M. W. 10, 000. The filtrated fluid was used as a dialyzable-transfer factor. The preparation was shown to transfer, antigen-specific cell-mediated immunity to native quinea pigs; this was especially true of the polypeptide rich antigen of Candida albicans. However, transfer did not occur when other antigens, the polysaccharide rich antigen of Candida albicans, purified protein derivative (PPD), Cryptococuccin, ovalbumin (OVA) and bovine serum albumin (BSA), were given simultaneously, as shown by results of the delayed skin test, histological examination and macrophage migration inhibition test. Reactivity was demonstrated when test antigens were given 1 or 2 days after the transfer factor treatment.

収録刊行物

• 真菌と真菌症

  真菌と真菌症 26 (4), 310-317, 1985

  日本医真菌学会

キーワード

• トランスファー・ファクター

詳細情報

• CRID: 1390001204210840192
• NII論文ID: 130003671323
• DOI: 10.3314/jjmm1960.26.310
• ISSN: 18846971
• ISSN: 05830516
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可