Antifungal activity of GBR-14206, a new imidazole derivative: In vitro studies.

• Morita Tatsuya

  Research Laboratories, Morishita Pharmaceutical Co., Ltd.

• Ishizuka Yasuhiro

  Research Laboratories, Morishita Pharmaceutical Co., Ltd.

• Yaginuma Hideya

  Research Laboratories, Morishita Pharmaceutical Co., Ltd.

• Matsuda Mitsuko

  Research Laboratories, Morishita Pharmaceutical Co., Ltd.

• Nozawa Yoshinori

  Department of Biochemistry, Gifu University School of Medicine

書誌事項

タイトル別名

• <i>In Vitro</i> Studies

抄録

The antifungal activity of GBR-14206, a new imidazole derivative, was evaluated in comparison with those of clotrimazole (CTZ) and miconazole (MCZ) using an agar dilution procedure.<br>GBR-14206 showed a potent activity against a wide range of pathogenic fungi including those associated with deep-seated and subcutaneous mycosis; it inhibited some standard strains of C. albicans at concentrations of 12.5μg/ml or less. Similarly, clinical isolates from various mycoses were also highly susceptible to GBR-14206 (MIC range; 0.0125-6.25μg/ml). The most striking activity of GBR-14206 was displayed against Cryptococcus neoformans (MIC range; 0.0125-0.05μg/ml), which was far superior to MCZ and CTZ. Against C. albicans, Trichophyton spp., and Microsporum spp., the activity of GBR-14206 was more moderate than MCZ and CTZ. Against Sporothrix schenckii, GBR-14206 had a lower mean MIC value than that of CTZ and was similar to MCZ. On the other hand, against Aspergillus spp., GBR-14206 was less effective than MCZ and CTZ. Fungal susceptibility of GBR-14206 tended to be enhanced with increasing medium pH. The activity was also lowered by addition of calf serum.

収録刊行物

• 真菌と真菌症

  真菌と真菌症 30 (2), 139-142, 1989

  日本医真菌学会

キーワード

• antifungal activity
• new imidazole derivative
• GBR-14206

詳細情報

• CRID: 1390001204213166464
• NII論文ID: 130003671413
• DOI: 10.3314/jjmm1960.30.139
• ISSN: 18846971
• ISSN: 05830516
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可