抗真菌剤硝酸スルコナゾールのＴｒｉｃｏｐｈｙｔｏｎ　ｒｕｂｒｕｍ発育菌糸の表層構造に及ぼす超微形態学的影響

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  • Structural effects of sulconazole nitrate on the hyphal growth of Trichophyton rubrum.

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The structural effects of sulconazole nitrate on the cell surface of the hyphae of Trichophyton rubrum were studied by low voltage scanning electron microscopy (SEM) and transmission electron microscopy on cells prepared by freeze-replica method.<BR>SEM revealed that the control hyphae that germinated from the micro-conidia grown without drug had highly developed growth showing a smooth surface, straight extensions and consistent width. In contrast, the hyphae from micro-conidia grown with the drug demonstrated structural changes depending on the drug concentration : 1) when MIC of the drug was used, growth of the extensions was inhibited and there were structural changes (wavy, curling and swollen tip); 2) with sub-MIC of the drug there was exfoliation of the hyphal wall and the hyphal surface was wrinkled.<BR>In the specimens fractured by freeze-replica method, the cell membrane was not affected but the cell wall was damaged by the MIC of the drug. This might result in induction of the inhibition of the hyphal growth of T. rubrum.

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